3.5.3 Pharmacology I
Lab 6 Evaluation the Action of Xylocaine on Rabbit's Skin
Developed by Prova Biswas
To observe the local anesthetic action of Xylocaine (2% w/v) on the skin (i.d. injection) of a Rabbit.
Local anesthetics are drugs, which upon topical application or local injection cause reversible loss of sensory perception, especially of pain, in a restricted
area of body. They block the generation and conduction of nerve impulse at all parts of the neurons,
where they come in contact, without causing any structural damage. Local anesthetics block nerve
conduction by decreasing the entry of Na+ ions during upstroke of action potential. The site of action
of local anesthetics is peripheral nerves; therefore, the consciousness is unaltered after application
of a local anesthetic.
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