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B.Pharm Lab. Instruction Manuals

Pharmacology I

APHE Anatomy, Physiology, and Health Education

Pharmaceutical Analysis

Pharmacy study material

Bones and Skeleton System

Bone disease (Gout) (Rheumatoid arthritis) (Osteoarthritis) (Osteoporosis)

Cancer and music therapy

Memory of water

3.5.3 Pharmacology I

Xylocaine structure

Lab 6 Evaluation the Action of Xylocaine on Rabbit's Skin

Developed by Prova Biswas

Aim

To observe the local anesthetic action of Xylocaine (2% w/v) on the skin (i.d. injection) of a Rabbit.

Theory

Local anesthetics are drugs, which upon topical application or local injection cause reversible loss of sensory perception, especially of pain, in a restricted area of body. They block the generation and conduction of nerve impulse at all parts of the neurons, where they come in contact, without causing any structural damage. Local anesthetics block nerve conduction by decreasing the entry of Na+ ions during upstroke of action potential. The site of action of local anesthetics is peripheral nerves; therefore, the consciousness is unaltered after application of a local anesthetic.


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